The ministry's Occupational Safety and Health Division responded immediately to the crane incident at the construction worksite in Punggol Central.
Preliminary investigations showed that five workers were dismantling a tower crane when the boom of the crane gave way and fell to the ground.
One worker was killed. The 32-year-old Malaysian was extricated by SCDF officers and was pronounced dead by paramedics at 6.05pm.
Three other foreign workers - a Thai, a Chinese and a Bangladeshi - were injured and were sent to Changi General Hospital for observation.